A conformational study of the 10–23 DNAzyme <i>via</i> programmed DNA self-assembly-Reference-Cited by-同舟云学术

A conformational study of the 10–23 DNAzyme via programmed DNA self-assembly

Published:2022 Issue:42 Volume:58 Page:6188-6191
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Mao Dake¹^ORCID,Li Qian¹²,Li Qian¹,Wang Pengfei³^ORCID,Mao Chengde¹^ORCID

Affiliation:

1. Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA

2. College of Life Sciences, Northwest University, Xi’an, Shaanxi 710069, China

3. Institute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

Abstract

We have developed a strategy to study the interhelical angle of two DNA duplexes in nucleic acids as exemplified by the 10–23 DNAzyme. The nucleic acids are programmed to assemble into large 2D arrays to reduce random conformation fluctuation and facilitate the conformation study.

Funder

National Science Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC01144A

Reference44 articles.

1. A DNA enzyme that cleaves RNA

2. A DNA metalloenzyme with DNA ligase activity

3. DNAzymes for sensing, nanobiotechnology and logic gate applications

4. Catalytic Nucleic Acids: Biochemistry, Chemical Biology, Biosensors, and Nanotechnology

5. A Highly Sensitive and Selective Catalytic DNA Biosensor for Lead Ions

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