Effective synthesis, development and application of a highly fluorescent cyanine dye for antibody conjugation and microscopy imaging-Reference-Cited by-同舟云学术

Effective synthesis, development and application of a highly fluorescent cyanine dye for antibody conjugation and microscopy imaging

Published:2023 Issue:44 Volume:21 Page:8829-8836
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Szepesi Kovács Dénes¹²³,Kontra Bence⁴⁵⁶^ORCID,Chiovini Balázs⁷,Müller Dalma⁶⁸⁹,Tóth Estilla Zsófia³⁶¹⁰,Ábrányi-Balogh Péter¹²³^ORCID,Wittner Lucia³¹⁰,Várady György¹¹^ORCID,Turczel Gábor¹²^ORCID,Farkas Ödön¹³^ORCID,Owen Michael C.¹⁴¹⁵,Katona Gergely⁷^ORCID,Győrffy Balázs³⁸⁹,Keserű György Miklós¹²³^ORCID,Mucsi Zoltán⁴⁵¹⁴^ORCID,Rózsa Balázs J.⁴⁷¹⁶^ORCID,Kovács Ervin⁵¹⁷^ORCID

Affiliation:

1. Medicinal Chemistry Research Group, HUN-REN Research Centre for Natural Sciences, H-1117 Budapest, Hungary

2. Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Hungary

3. National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary

4. Brain Vision Center, H-1094 Budapest, Hungary

5. Femtonics Ltd., H-1094 Budapest, Hungary

6. Semmelweis University Doctoral School, H-1085 Budapest, Hungary

7. Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, H-1444 Budapest, Hungary

8. Oncology Biomarker Research Group, HUN-REN Research Centre for Natural Sciences, H-1117 Budapest, Hungary

9. Department of Bioinformatics, Semmelweis University, H-1094, Budapest, Hungary

10. Integrative Neuroscience Research Group, HUN-REN Research Centre for Natural Sciences, H-1117 Budapest, Hungary

11. Molecular Cell Biology Research Group, HUN-REN Research Centre for Natural Sciences, H-1117 Budapest, Hungary

12. NMR Research Laboratory, HUN-REN Research Centre for Natural Sciences, H-1117 Budapest, Hungary

13. Department of Organic Chemistry, Eötvös Loránd University, H-1117 Budapest, Hungary

14. Institute of Chemistry, University of Miskolc, Miskolc H-3515, Hungary

15. Higher Education and Industrial Cooperation Centre, University of Miskolc, Miskolc H-3515, Hungary

16. Laboratory of 3D Functional Network and Dendritic Imaging, HUN-REN Institute of Experimental Medicine, H-1083 Budapest, Hungary

17. Polymer Chemistry and Physics Research Group, HUN-REN Research Centre for Natural Sciences, H-1117 Budapest, Hungary

Abstract

An azido cyanine dye was synthesized and characterized by computational and experimental techniques and applied in tumor cell imaging.

Funder

Magyar Tudományos Akadémia

National Research, Development and Innovation Office

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01471A

Reference53 articles.

1. Cyanine polyene reactivity: scope and biomedical applications

2. Near-infrared heptamethine cyanines (Cy7): from structure, property to application

3. Antibody-based imaging strategies for cancer

4. Fluorescence Lifetime-Based Tumor Contrast Enhancement Using an EGFR Antibody–Labeled Near-Infrared Fluorophore

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