Catalyst-free visible-light-induced condensation to synthesize bis(indolyl)methanes and biological activity evaluation of them as potent human carboxylesterase 2 inhibitors-Reference-Cited by-同舟云学术

Catalyst-free visible-light-induced condensation to synthesize bis(indolyl)methanes and biological activity evaluation of them as potent human carboxylesterase 2 inhibitors

Published:2019 Issue:68 Volume:9 Page:40168-40175
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhao Yi-Shu¹²³⁴,Ruan Hong-Li⁵⁶⁷⁴,Wang Xiu-Yang¹²³⁴,Chen Chen⁵⁶⁷⁴,Song Pei-Fang¹²³⁴,Lü Cheng-Wei⁵⁶⁷⁴,Zou Li-Wei¹²³⁴^ORCID

Affiliation:

1. Institute of Interdisciplinary Integrative Medicine Research

2. Shanghai University of Traditional Chinese Medicine

3. Shanghai 201203

4. People's Republic of China

5. School of Chemistry and Chemical Engineering

6. Liaoning Normal University

7. Dalian 116029

Abstract

Bis(indolyl)methanes were synthesized by a green protocol. Primary structure–activity relationship analysis showed that the bisindolyl structure is essential for CES2 inhibition.

Funder

Department of Science and Technology of Liaoning Province

National Natural Science Foundation of China

National Basic Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA08593A

Reference57 articles.

1. Structure, function and regulation of carboxylesterases