Outstanding drug loading capacity by water stable microporous MOF: a potential drug carrier

Author:

Bag Partha Pratim12345,Wang Dong12345,Chen Zhuo12345,Cao Rong12345

Affiliation:

1. State Key Laboratory of Structural Chemistry

2. Fujian Institute of Research on the Structure of Matter

3. Chinese Academy of Sciences

4. Fuzhou 350002

5. P. R. China

Abstract

A robust, highly water stable, microporous MOF, [Zn8(O)2(CDDB)6(DMF)4(H2O)] {where CDDB = 4,4′-(9-H carbazole-3,6-diyl)dibenzoic acid}, was synthesized based on an open N–H site by a solvothermal process and exhibited an outstanding loading capacity and satisfactory release capability for 5-fluorouracil, with a negligible cytotoxicity effect.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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