Unveiling the electrophilic aromatic substitution reactions of pyridine derivatives with nitronium ion through molecular electron density theory-Reference-Cited by-同舟云学术

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Unveiling the electrophilic aromatic substitution reactions of pyridine derivatives with nitronium ion through molecular electron density theory

Published:2023 Issue:11 Volume:47 Page:5193-5202
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Domingo Luis R.¹^ORCID,Aurell María José¹^ORCID

Affiliation:

1. Department of Organic Chemistry, University of Valencia, Dr Moliner 50, 46100, Burjassot, Valencia, Spain

Abstract

The nitration of pyridine Py and pyridine-1-oxide PyO have low activation Gibbs free energies, but in the medium acid, the corresponding pyridinium cation PyH+ is strongly deactivated for the electrophilic aromatic substitution.

Funder

Ministerio de Ciencia, Innovación y Universidades

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D2NJ05845F

Reference52 articles.

1. R.Taylor Electrophilic Aromatic Substitution , John Wiley Sons , 1990

2. M. B.Smith and J.March , March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure , John Wiley & Sons, Inc. , NY , 2013

3. F. A.Carey and R. J.Sundberg , Advanced Organic Chemistry, Part A: Structure and Mechanisms , Springer , New York , 2008

4. Über die Darstellung von Nitro‐pyridin

5. Nitropyridines: Synthesis and reactions

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