Potentiality of chitosan hybridized magnesium doped-hydroxyapatite (CH/Mg·HAP) for enhanced carrying of oxaliplatin: loading, release, kinetics, and cytotoxicity

Author:

Bin Jumah May N.1,Al Othman Sarah I.1,Alomari Awatif Abdulaziz1,Allam Ahmed A.2,Abukhadra Mostafa R.34ORCID

Affiliation:

1. Biology Department, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

2. Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Kingdom of Saudi Arabia

3. Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef 65211, Egypt

4. Materials Technologies and their Applications Lab, Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef City, Egypt

Abstract

Magnesium-enriched hydroxyapatite was synthesized and integrated with chitosan, forming a bio-compatible biocomposite (CH/Mg·HAP) to be applied as a carrier of oxaliplatin (OXN) with enhanced loading, release, and therapeutic activities.

Funder

Princess Nourah Bint Abdulrahman University

Publisher

Royal Society of Chemistry (RSC)

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