TfOH-promoted multichannel transformations of trifluoromethyl side chain substituted thiophene and furan families to access antimicrobial agents

Author:

Khoroshilova Olesya V.1ORCID,Borovkova Kristina E.2ORCID,Nikiforova Lia R.2,Salmova Julia V.2,Taraskin Artem O.2,Spiridonova Daria V.3ORCID,Vasilyev Aleksander V.14ORCID

Affiliation:

1. Department of Organic Chemistry, Institute of Chemistry, Saint Petersburg State University, Universitetskaya nab., 7/9, Saint Petersburg, 199034, Russia

2. RMC “HOME OF PHARMACY” Leningrad region., Vsevolozhsk district, p. Kuzmolovsky, 245, 188663, Russia

3. Research Center for X-ray Diffraction Studies, Research Park, Saint Petersburg State University, Universitetskiy pr. 26, Saint Petersburg, Petrodvoretz, 198504, Russia

4. Department of Chemistry, Saint Petersburg State Forest Technical University, Institutsky per., 5, Saint Petersburg, 194021, Russia

Abstract

TMS-ethers of the CF3-benzyl type alcohols of the thiophene and (benzo)furan series undergo transformations in TfOH, leading to the formation of various products of side chain arylation, dehalogenation, arylation of the heteroaromatic core, and others.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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