Improvement of the pharmacological properties of amidated kyotorphin by means of iodination-Reference-Cited by-同舟云学术

Improvement of the pharmacological properties of amidated kyotorphin by means of iodination

Published:2016 Issue:5 Volume:7 Page:906-913
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Oliveira Maria Cristina¹²³⁴⁵,Gano Lurdes¹²³⁴⁵,Santos Isabel¹²³⁴⁵,Correia João D. G.¹²³⁴⁵,Serrano Isa D.⁶⁷⁸⁵,Santos Sónia Sá⁶⁷⁸⁵,Ribeiro Marta⁶⁷⁸⁵,Perazzo Juliana⁶⁷⁸⁵,Tavares Isaura⁹¹⁰¹¹¹²⁵,Heras Montserrat¹³¹⁴¹⁵¹⁶¹⁷,Bardaji Eduard¹³¹⁴¹⁵¹⁶¹⁷,Castanho Miguel A.⁶⁷⁸⁵

Affiliation:

1. Centro de Ciências e Tecnologias Nucleares

2. Instituto Superior Técnico

3. Universidade de Lisboa

4. 2695-066 Bobadela LRS

5. Portugal

6. Instituto de Medicina Molecular

7. Faculdade de Medicina de Lisboa

8. 1649-028 Lisboa

9. Faculdade de Medicina do Porto

10. Departamento de Biologia Experimental

11. Universidade do Porto

12. 4200-319 Porto

13. Laboratori d'Innovació en Processos i Productes de Síntesi Orgànica (LIPPSO)

14. Departament de Química

15. Universitat de Girona

16. 17071 Girona

17. Spain

Abstract

Iodination resulted in a slow release-like process that converted KTP, a drug rapidly cleared and having a fast transient effect, into a pro drug having delayed and prolonged action.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00028B

Reference17 articles.

1. A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser

2. Morphine-like analgesia by a new dipeptide, L-Tyrosyl-L-Arginine (kyotorphin) and its analogue

3. Isolation and identification of an analgesic opioid dipeptide kyotorphin (TYR-ARG) from bovine brain

4. Strategies To Target Kyotorphin Analogues to the Brain

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3. Formation and Occurrence of Iodinated Tyrosyl Dipeptides in Disinfected Drinking Water;Environmental Science & Technology;2018-02-28