Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation
Author:
Affiliation:
1. Small Molecule Drug Product Development, Biogen, 115 Broadway, Cambridge, MA 02142, USA
2. NanoImaging Services, 4940 Carroll Canyon Road, San Diego, CA 92121, USA
Abstract
Funder
National Institute of General Medical Sciences
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC00221C
Reference27 articles.
1. The Significance of Chirality in Drug Design and Development
2. Center for Drug Evaluation and Research, Development of New Stereoisomeric Drugs, https://www.fda.gov/regulatory-information/search-fda-guidance-documents/development-new-stereoisomeric-drugs , 1992
3. Determination of Absolute Configuration of Chiral Molecules Using Vibrational Optical Activity: A Review
4. The Assignment of Absolute Configuration by NMR
5. Determination of absolute configuration—An overview related to this Special Issue
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1. Structural Elucidation and Absolute Stereochemistry for Pharma Compounds Using MicroED;Organic Letters;2024-08-08
2. Chirality Determination of Nanocrystals by Electron Crystallography;The Journal of Physical Chemistry Letters;2024-06-27
3. TAAM refinement on high-resolution experimental and simulated 3D ED/MicroED data for organic molecules;Acta Crystallographica Section C Structural Chemistry;2024-06-27
4. Accurate structure models and absolute configuration determination using dynamical effects in continuous-rotation 3D electron diffraction data;Nature Chemistry;2023-04-20
5. MicroED in drug discovery;Current Opinion in Structural Biology;2023-04
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