Rapid optimisation of API crystallisation in a segmented flow reactor with a continuous, variable temperature gradient-Reference-Cited by-同舟云学术

Rapid optimisation of API crystallisation in a segmented flow reactor with a continuous, variable temperature gradient

Published:2023 Issue:1 Volume:8 Page:77-83
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Robertson Karen¹²^ORCID,Seeberger Peter H.²³^ORCID,Gilmore Kerry²³^ORCID

Affiliation:

1. Faculty of Engineering, University of Nottingham, Nottingham, UK

2. Max-Planck-Institute, Potsdam-Golm, Germany

3. Chemistry, University of Connecticut, 55 N. Eagleville Rd, Storrs, Connecticut, USA

Abstract

A continuous flow reactor capable of a continuous, variable temperature gradient allows for the rapid optimization of reproducible crystallization conditions and control of crystal growth of small organic molecules.

Funder

Max-Planck-Förderstiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RE/D2RE00183G

Reference44 articles.

1. Polymorphism and Crystallization of Active Pharmaceutical Ingredients (APIs)

2. Insights into the structure-property relationship of pharmaceutical co-crystals: Charge density and quantum chemical approaches

3. Some thoughts about the single crystal growth of small molecules

4. The Hitchhiker’s Guide to Flow Chemistry

5. Analysis of Crystal Size Dispersion Effects in a Continuous Coiled Tubular Crystallizer: Experiments and Modeling

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