Sesquiterpenoids and hexanorcucurbitacin from <i>Aquilaria malaccensis</i> agarwood with anti-inflammatory effects by inhibiting the STAT1/AKT/MAPK/NLRP3 pathway-Reference-Cited by-同舟云学术

Sesquiterpenoids and hexanorcucurbitacin from Aquilaria malaccensis agarwood with anti-inflammatory effects by inhibiting the STAT1/AKT/MAPK/NLRP3 pathway

Published:2024 Issue:13 Volume:14 Page:9391-9405
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ma Chi Thanh¹²^ORCID,Huang Tianqi²³,Yu Jae Sik²^ORCID,Ly Tu Loan⁴^ORCID,Vu Huynh Kim Long⁴,Kwon Sung Won⁵^ORCID,Park Jeong Hill⁵^ORCID,Yang Hyun Ok²^ORCID

Affiliation:

1. Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41-43 Dinh Tien Hoang St, Dist 1, Ho Chi Minh City 700000, Vietnam

2. Department of Integrative Biological Sciences and Industry & Convergence Research Center for Natural Products, Sejong University, 209, Neungdong-ro, Gwangjin-gu, Seoul 05006, Republic of Korea

3. Korea Institute of Science and Technology (KIST) School, Korea University of Science and Technology (UST), 5 Hwarang-ro 14-gil, Wolgok 2(i)-dong, Seongbuk-gu, Seoul 02792, Republic of Korea

4. Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam

5. Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea

Abstract

A rare hexanortriterpenoid significantly attenuated the proinflammatory mediators, STAT1/AKT/MAPK, and MAPK/NLRP3 signaling pathways for preventing neuroinflammatory disorders in BV2 microglial cells.

Funder

National Research Foundation of Korea

Ministry of Science and ICT, South Korea

Rural Development Administration

National Foundation for Science and Technology Development

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D3RA08686K

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