A continuous flow investigation of sulfonyl chloride synthesis using <i>N</i>-chloroamides: optimization, kinetics and mechanism-Reference-Cited by-同舟云学术

A continuous flow investigation of sulfonyl chloride synthesis using N-chloroamides: optimization, kinetics and mechanism

Published:2022 Issue:12 Volume:7 Page:2582-2592
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Polterauer Dominik¹²^ORCID,Roberge Dominique M.³^ORCID,Hanselmann Paul³,Littich Ryan³,Hone Christopher A.¹²^ORCID,Kappe C. Oliver¹²^ORCID

Affiliation:

1. Center for Continuous Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, A-8010 Graz, Austria

2. Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria

3. Chemical Manufacturing Technologies, Lonza AG, CH-3930 Visp, Switzerland

Abstract

We develop a continuous flow protocol for the synthesis of sulfonyl chlorides from disulfides and thiols, using 1,3-dichloro-5,5-dimethylhydantoin (DCH) as a dual-function reagent for oxidative chlorination.

Funder

Bundesministerium für Digitalisierung und Wirtschaftsstandort

Steirische Wirtschaftsför-derungsgesellschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RE/D2RE00280A

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