Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation-Reference-Cited by-同舟云学术

Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation

Published:2020 Issue:9 Volume:11 Page:1023-1031
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Poirier Marion¹²³⁴,Pujol-Giménez Jonai⁵²³⁴⁶^ORCID,Manatschal Cristina⁷⁸⁹⁴^ORCID,Bühlmann Sven¹²³⁴,Embaby Ahmed¹²³⁴,Javor Sacha¹²³⁴^ORCID,Hediger Matthias A.⁵²³⁴⁶^ORCID,Reymond Jean-Louis¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry

2. University of Bern

3. 3012 Bern

4. Switzerland

5. Institute of Biochemistry and Molecular Medicine

6. Membrane Transport Discovery Lab

7. Department of Biochemistry

8. University of Zürich

9. Zürich

Abstract

Activity optimization of a pyrazolyl-pyrimidone against the iron transporter SLC11A2 (hDMT1) and mechanistic studies revealed that this class of inhibitors act by metal chelation.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/D0MD00085J

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