Preparation and characterization of flexible furosemide-loaded biodegradable microneedles for intradermal drug delivery-Reference-Cited by-同舟云学术

Preparation and characterization of flexible furosemide-loaded biodegradable microneedles for intradermal drug delivery

Published:2022 Issue:22 Volume:10 Page:6486-6499
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Abu-Much Arsalan¹²^ORCID,Darawshi Raya³,Dawud Hala³,Kasem Haytam⁴,Abu Ammar Aiman³^ORCID

Affiliation:

1. Leviev Heart Center, Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel

2. Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel

3. Department of Pharmaceutical Engineering, Azrieli College of Engineering Jerusalem, 26 Yaakov Shreibom Street, Ramat Beit Hakerem, Jerusalem 9103501, Israel

4. Department of Mechanical Engineering, Azrieli College of Engineering Jerusalem, Jerusalem, Israel

Abstract

Furosemide-loaded microneedles, comprising PLGA needle tips and a flexible base, were fabricated and characterized in vitro and ex vivo. The microneedles exhibited an initial burst release followed by sustained release of furosemide.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D2BM01143C

Reference71 articles.

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