A synthetic route towards 3,4-disubstituted pyrrolidin-2-ones via a Michael addition and reductive ring closing strategy

Author:

Dawange Monali1234,Parekh Nikita1234,Kumbhar Avinash1234,Dehaen Wim51678,Kusurkar Radhika1234ORCID

Affiliation:

1. Department of Chemistry

2. S P Pune University

3. Pune 411007

4. India

5. Molecular Design and Synthesis

6. KU Leuven

7. 3001 Leuven

8. Belgium

Abstract

2-Pyrrolidinone scaffolds with a wide range of substituents were synthesized with good yield and diastereoselectivity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Reference52 articles.

1. J. A. Joule and K.Mills, Heterocycl. Chem., Blackwell Science, Oxford, 2000

2. A. R. Katritzky , Comprehensive Heterocyclic Chemistry: The structure, reactions, synthesis and uses of heterocyclic compounds, Pergamon Press, 1984, vol. 1–8

3. Epolactaene binds human Hsp60 Cys442 resulting in the inhibition of chaperone activity

4. Epolactaene, a Novel Neuritogenic Compound in Human Neuroblastoma Cells, Produced by a Marine Fungus.

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