Modular allylation of C(sp<sup>3</sup>)–H bonds by combining decatungstate photocatalysis and HWE olefination in flow-Reference-Cited by-同舟云学术

Modular allylation of C(sp³)–H bonds by combining decatungstate photocatalysis and HWE olefination in flow

Published:2022 Issue:24 Volume:13 Page:7325-7331
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Capaldo Luca¹^ORCID,Bonciolini Stefano¹^ORCID,Pulcinella Antonio¹^ORCID,Nuño Manuel²,Noël Timothy¹^ORCID

Affiliation:

1. Flow Chemistry Group, Van’t Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands

2. Vapourtec Ltd, Park Farm Business Centre, Fornham St Genevieve, Bury St Edmunds, Suffolk IP28 6TS, UK

Abstract

We report a flow platform for the modular allylation of strong aliphatic C(sp3)–H bonds based on the merger of photocatalytic HAT and a HWE reaction. This approach enables both early- and late-stage diversification of various hydroalkanes.

Funder

H2020 Marie Skłodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC01581A

Reference61 articles.

1. Late-Stage Diversification: A Motivating Force in Organic Synthesis

2. Late-stage C–H functionalization offers new opportunities in drug discovery

3. The price of innovation: new estimates of drug development costs