A monofunctional Pt(<scp>ii</scp>) complex combats triple negative breast cancer by triggering lysosome-dependent cell death-Reference-Cited by-同舟云学术

A monofunctional Pt(ii) complex combats triple negative breast cancer by triggering lysosome-dependent cell death

Published:2024 Issue:8 Volume:53 Page:3808-3817
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Shen Xiaomin¹,Peng Yue¹,Yang Zidong¹,Li Renhao¹^ORCID,Zhou Haixia²,Ye Xiaoxia¹,Han Zhong³^ORCID,Shi Xiangchao¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, P. R. China

2. The Key Laboratory of Pediatric Hematology and oncology Diseases of Wenzhou, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325088, P. R. China

3. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, P. R. China

Abstract

A monofunctional Pt(ii) complex PtL induces DNA single-strand breaks in triple negative breast cancer and triggers lysosome-dependent cell death by modulating lysosomal function.

Funder

National Natural Science Foundation of China

Zhejiang Provincial Outstanding Youth Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D3DT03598K

Reference29 articles.

1. Functionalization of Platinum Complexes for Biomedical Applications

2. Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?

3. Monofunctional Platinum(II) Anticancer Agents

4. The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

5. Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile