Separation of a diastereomeric diol pair using the mechanical properties of crystals-Reference-Cited by-同舟云学术

Separation of a diastereomeric diol pair using the mechanical properties of crystals

Published:2021 Issue:40 Volume:23 Page:7056-7060
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Gamidi Rama Krishna¹^ORCID,Dandawate Monica¹,Tothadi Srinu¹^ORCID,Choudhury Rahul¹²,Nangia Ashwini K.¹³^ORCID,Reddy D. Srinivasa¹²

Affiliation:

1. Organic Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India

2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

3. School of Chemistry, University of Hyderabad, Hyderabad 500046, India

Abstract

The visually indistinguishable acicular crystals of a (2S,3R/S)-3-ethyl-1-phenylhex-5-ene-2,3-diol (ephd) diastereomeric pair are separated via the mechanical response based on elastic (2S,3R, right) and brittle (2S,3S, left) crystals.

Funder

University Grants Commission

Department of Biotechnology, Ministry of Science and Technology

Science and Engineering Research Board

Council of Scientific and Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CE/D1CE01055G

Reference50 articles.

1. Synthesis, crystallization and characterization of diastereomeric salts formed by ephedrine and malic acid in water

2. Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes

3. Single-run reversed-phase HPLC method for determining sertraline content, enantiomeric purity, and related substances in drug substance and finished product

4. Biological Actions of Formoterol Isomers

5. Synthesis-Guided Structure Revision of the Sarcodonin, Sarcoviolin, and Hydnellin Natural Product Family

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