Pyridine-based small molecule inhibitors of SARM1 alleviate cell death caused by NADase activity-Reference-Cited by-同舟云学术

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Pyridine-based small molecule inhibitors of SARM1 alleviate cell death caused by NADase activity

Published:2024 Issue:66 Volume:60 Page:8724-8727
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Tang Qingxuan¹²³⁴⁵,Yin Hang¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Membrane Biology, Tsinghua University, Beijing 100084, China

2. School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China

3. Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China

4. Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, China

5. Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program, Tsinghua University, Beijing 100084, China

Abstract

TH-408 counters toxicity by inhibiting SARM1 activation and NAD+ depletion, offering a promising approach to cell death prevention.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC02650K

Reference22 articles.

1. dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

2. NAD + cleavage activity by animal and plant TIR domains in cell death pathways

3. The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

4. Gene therapy targeting SARM1 blocks pathological axon degeneration in mice

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