Novel glycyrrhetinic acid conjugated pH-sensitive liposomes for the delivery of doxorubicin and its antitumor activities
Author:
Affiliation:
1. School of Pharmacy
2. Shenyang Pharmaceutical University
3. Shenyang
4. P.R. China
5. School of Pharmaceutical Engineering
6. Hongqi Hospital of Mudanjiang Medical University
7. Mudanjiang
8. College Pharmacy of Jiamusi University
9. Jiamusi
Abstract
A novel pH-sensitive conjugate glycyrrhetinic acid–polyethylene glycol–Schiff bond–cholesterol (GPSC) has been synthesized successfully and used to construct doxorubicin-loaded liposomes with both pH-sensitive features and active targeting ability.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA01580H
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