Novel glycyrrhetinic acid conjugated pH-sensitive liposomes for the delivery of doxorubicin and its antitumor activities

Author:

Chen Qing1234,Ding Huaiwei524,Zhou Jinxing1234,Zhao Xiufeng674,Zhang Jiulong1234,Yang Chunrong894,Li Kexin1234,Qiao Mingxi1234,Hu Haiyang1234,Ding Pingtian1234,Zhao Xiuli1234

Affiliation:

1. School of Pharmacy

2. Shenyang Pharmaceutical University

3. Shenyang

4. P.R. China

5. School of Pharmaceutical Engineering

6. Hongqi Hospital of Mudanjiang Medical University

7. Mudanjiang

8. College Pharmacy of Jiamusi University

9. Jiamusi

Abstract

A novel pH-sensitive conjugate glycyrrhetinic acid–polyethylene glycol–Schiff bond–cholesterol (GPSC) has been synthesized successfully and used to construct doxorubicin-loaded liposomes with both pH-sensitive features and active targeting ability.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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