Molecular construction of HIV-gp120 discontinuous epitope mimics by assembly of cyclic peptides on an orthogonal alkyne functionalized TAC-scaffold-Reference-Cited by-同舟云学术

Molecular construction of HIV-gp120 discontinuous epitope mimics by assembly of cyclic peptides on an orthogonal alkyne functionalized TAC-scaffold

Published:2016 Issue:2 Volume:14 Page:701-710
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Werkhoven P. R.¹²³⁴⁵,Elwakiel M.¹²³⁴⁵,Meuleman T. J.¹²³⁴⁵,Quarles van Ufford H. C.¹²³⁴⁵,Kruijtzer J. A. W.¹²³⁴⁵,Liskamp R. M. J.¹²³⁴⁵

Affiliation:

1. Division of Medicinal Chemistry & Chemical Biology

2. Department of Pharmaceutical Sciences

3. Faculty of Science

4. Utrecht University

5. 3508 TB Utrecht

Abstract

An orthogonally alkyne functionalized TAC-scaffold was used for molecular construction of biologically active gp120 protein mimics containing different peptide loops.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB02014J

Reference23 articles.

1. A Selectively Deprotectable Triazacyclophane Scaffold for the Construction of Artificial Receptors

2. Cyclotriveratrylene (CTV) as a New Chiral Triacid Scaffold Capable of Inducing Triple Helix Formation of Collagen Peptides Containing either a Native Sequence or Pro-Hyp-Gly Repeats

3. Approaches to the Solid Phase of a Cyclotriveratrylene Scaffold-Based Tripodal Library as Potential Artificial Receptors

4. A novel strategy to mimic discontinuous protective epitopes using a synthetic scaffold

5. A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes

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