Tandem molecular self-assembly for selective lung cancer therapy with an increase in efficiency by two orders of magnitude-Reference-Cited by-同舟云学术

Tandem molecular self-assembly for selective lung cancer therapy with an increase in efficiency by two orders of magnitude

Published:2021 Issue:24 Volume:13 Page:10891-10897
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Zheng Debin¹²³⁴⁵,Liu Jingfei¹²³⁴⁵,Ding Yinghao⁶⁷⁸⁹,Xie Limin¹²³⁴⁵,Zhang Yingying¹²³⁴⁵,Chen Yaoxia¹²³⁴⁵,Peng Rong¹²³⁴⁵,Cai Miao¹²³⁴⁵,Wang Ling⁶⁷⁸⁹,Wang Huaimin¹⁰¹¹¹²¹³¹⁴^ORCID,Gao Jie¹²³⁴⁵^ORCID,Yang Zhimou¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Medicinal Chemical Biology

2. Key Laboratory of Bioactive Materials

3. Ministry of Education

4. College of Life Sciences

5. Collaborative Innovation Center of Chemical Science and Engineering

6. College of Pharmacy

7. Nankai University

8. Tianjin 300071

9. P. R. China

10. Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province

11. School of Science

12. Westlake University; Institute of Natural Sciences

13. Westlake Institute for Advanced Study

14. Hangzhou 310024

Abstract

By using elevated level of phosphatase and reductase in lung cancer cells, we designed a tandem molecular self-assembling prodrug that could selectively improve the therapeutic efficacy of HCPT against lung cancer by two orders of magnitude.

Funder

National Science Fund for Distinguished Young Scholars

National Natural Science Foundation of China

Young Elite Scientists Sponsorship Program by Tianjin

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D1NR01174J

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1. Cancer nanomedicine: progress, challenges and opportunities