Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates-Reference-Cited by-同舟云学术

Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates

Author:

Mullins Nicholas D.¹²³⁴⁵,Maguire Nuala M.¹²³⁴⁵,Ford Alan¹²³⁴⁵,Das Kalyan⁶⁷⁸⁹,Arnold Eddy⁶⁷⁸⁹,Balzarini Jan¹⁰¹¹¹²¹³,Maguire Anita R.¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. Analytical and Biological Chemistry Research Facility

3. Synthesis and Solid State Pharmaceutical Centre

4. University College

5. Cork

6. Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology

7. Rutgers University

8. Piscataway

9. USA

10. KU Leuven

11. Rega Institute for Medical Research

12. B-3000 Leuven

13. Belgium

Abstract

The importance of the α-carboxy phosphonoacetic acid moiety to achieve RT inhibition, without the need for prior phosphorylation, is confirmed.

Funder

KU Leuven

Science Foundation Ireland

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

Reference38 articles.

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