A mean-field theory for predicting single polymer collapse induced by neutral crowders

Author:

Chaboche Quentin12ORCID,Campos-Villalobos Gerardo3,Giunta Giuliana34ORCID,Dijkstra Marjolein3,Cosentino Lagomarsino Marco25,Scolari Vittore F.16ORCID

Affiliation:

1. Institut Curie, PSL Research University, Sorbonne Université, CNRS UMR168, Laboratoire Physique des Cellules et Cancer, 75005 Paris, France

2. IFOM ETS, The AIRC Institute of Molecular Oncology, 20139, Milan, Italy

3. Soft Condensed Matter, Debye Institute for Nanomaterials Science, Utrecht University, Princetonplein 5, 3584 CC Utrecht, The Netherlands

4. BASF SE, Carl-Bosch-Strasse 38, 67056 Ludwigshafen am Rhein, Germany

5. Physics Department, University of Milan, and INFN, Milan, Italy

6. Institut Curie, PSL Research University, Sorbonne Université, CNRS UMR3664, Laboratoire Dynamique du Noyau, 75005 Paris, France

Abstract

Depletion forces arising from molecular crowding compact single polymers. Simulations lead to a unified description. Collapse is governed by the packing fraction of crowders and the ratio of crowder to monomer size, and can be hindered by jamming.

Funder

Associazione Italiana per la Ricerca sul Cancro

Publisher

Royal Society of Chemistry (RSC)

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