A bespoke microfluidic pharmacokinetic compartment model for drug absorption using artificial cell membranes

Author:

Korner Jaime L.1234ORCID,Stephenson Elanna B.1234ORCID,Elvira Katherine S.1234ORCID

Affiliation:

1. Department of Chemistry

2. University of Victoria

3. Victoria

4. Canada

Abstract

A new type of pharmacokinetic compartment model using artificial cell membranes that predicts intestinal absorption three times more accurately than the current state of the art.

Funder

Natural Sciences and Engineering Research Council of Canada

British Columbia Knowledge Development Fund

Canada Foundation for Innovation

Canada Research Chairs

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Reference66 articles.

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2. T. D. Y. Chung , D. B.Terry and L. H.Smith , In vitro and in vivo assessment of ADME and PK properties during lead selection and lead optimization – Guidelines, benchmarks and rules of thumb , Eli Lilly & Company and the National Center for Advancing Translational Sciences , Bethesda (MD) , 2015

3. Institute of Medicine (US) Committee on Conflict of Interest in Medical Research, Education, and Practice , Conflict of interest in medical research, education, and practice , National Academies Press (US) , Washington (DC) , 2009

4. Innovation in the pharmaceutical industry: New estimates of R&D costs

5. Physicochemical Profiling (Solubility, Permeability and Charge State)

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