Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids-Reference-Cited by-同舟云学术

Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids

Published:2016 Issue:44 Volume:14 Page:10371-10385
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Glawar A. F. G.¹²³⁴⁵,Martínez R. F.¹²³,Ayers B. J.¹²³,Hollas M. A.¹²³,Ngo N.¹²³,Nakagawa S.⁶⁷⁸⁹,Kato A.⁶⁷⁸⁹,Butters T. D.⁴⁵²³,Fleet G. W. J.¹²³⁴⁵,Jenkinson S. F.¹²³

Affiliation:

1. Chemistry Research Laboratory

2. Oxford

3. UK

4. Oxford Glycobiology Institute

5. University of Oxford

6. Department of Hospital Pharmacy

7. University of Toyama

8. Toyama 930-0194

9. Japan

Abstract

β-N-Acetylhexosaminidase inhibition of pipecolic, proline and azetidine amides in a cellular setting has potential as an anti-invasive anti-cancer strategy.

Funder

Leverhulme Trust

Cancer Research UK

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01549B

Reference71 articles.

1. Glycan Evolution in Response to Collaboration, Conflict, and Constraint

2. Gangliosides and Gangliosidoses: Principles of Molecular and Metabolic Pathogenesis