Identification of a new series of benzothiazinone derivatives with excellent antitubercular activity and improved pharmacokinetic profiles-Reference-Cited by-同舟云学术

Identification of a new series of benzothiazinone derivatives with excellent antitubercular activity and improved pharmacokinetic profiles

Published:2018 Issue:20 Volume:8 Page:11163-11176
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Xiong Lu¹²³⁴⁵,Gao Chao¹²³⁴⁵,Shi Yao-Jie¹²³⁴⁵,Tao Xin¹²³⁴⁵,Rong Juan¹²³⁴⁵,Liu Kun-Lin¹²³⁴⁵,Peng Cui-Ting¹²³⁴⁵,Wang Ning-Yu⁶⁷⁵,Lei Qian¹²³⁴⁵,Zhang Yi-Wen¹²³⁴⁵,Yu Luo-Ting¹²³⁴⁵^ORCID,Wei Yu-Quan¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center

2. West China Hospital

3. Sichuan University and Collaborative Innovation Center

4. Chengdu 610041

5. China

6. School of Life Science and Engineering

7. Southwest JiaoTong University

Abstract

Nitrobenzothiazinone (BTZ) is a promising scaffold with potent activity against M. tuberculosis by inhibiting decaprenylphosphoryl-beta-d-ribose 2′-oxidase (DprE1).

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA00720A

Reference28 articles.

1. Treatment of pulmonary tuberculosis: past and present†

2. Tuberculosis: The drug development pipeline at a glance

3. Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

4. Towards a new combination therapy for tuberculosis with next generation benzothiazinones

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