Coomassie brilliant blue G-250 acts as a potential chemical chaperone to stabilize therapeutic insulin-Reference-Cited by-同舟云学术

Coomassie brilliant blue G-250 acts as a potential chemical chaperone to stabilize therapeutic insulin

Published:2023 Issue:52 Volume:59 Page:8095-8098
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Pariary Ranit¹,Dolui Sandip²,Shome Gourav³^ORCID,Mohid Sk Abdul¹,Saha Achintya⁴^ORCID,Ratha Bhisma N¹⁵^ORCID,Harikishore Amaravadhi⁶,Jana Kuladip³,Mandal Atin K³,Bhunia Anirban¹^ORCID,Maiti Nakul C²^ORCID

Affiliation:

1. Department of Biophysics, Bose Institute, Salt Lake, Kolkata 700 091, India

2. Structural Biology and Bioinformatics Division, CSIR-IICB, 4 Raja S C Mullick Road, Kolkata 700 032, India

3. Division of Molecular Medicine, Bose Institute, Salt Lake, Kolkata 700 091, India

4. Department of Chemical Technology, University of Calcutta, 92 APC Road, Kolkata 700 009, India

5. Centurian University of Technology and Management, Odisha 761211, India

6. School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore

Abstract

Coomassie Brilliant Blue G-250 acts as a chemical chaperone, increasing therapeutic insulin bioavailability by stabilising the active state of human insulin, disrupting aggregates to nontoxic smaller species, and enhancing insulin secretion.

Funder

Department of Biotechnology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC01791E

Reference27 articles.

1. Insulin-derived amyloidosis: The insulin ball, amyloidoma

2. Insulin–eukaryotic model membrane interaction: Mechanistic insight of insulin fibrillation and membrane disruption

3. Pharmaceutical amyloidosis associated with subcutaneous insulin and enfuvirtide administration

4. Structural Insight of Amyloidogenic Intermediates of Human Insulin

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