Construction of histidine-containing hydrocarbon stapled cell penetrating peptides for in vitro and in vivo delivery of siRNAs
Author:
Affiliation:
1. Institute of Molecular Biology and Genetics
2. Seoul National University
3. Seoul 08826
4. Korea
5. Department of Chemistry & Education
6. Hugel, Inc.
7. Chuncheon 24206
8. Department of Chemistry
9. Sungkyunkwan University
10. Suwon
Abstract
A hydrocarbon stapled peptide, LKH-stEK, promotes delivery of nanomolar siRNAs leading to efficient gene silencing in mouse skin.
Funder
National Research Foundation of Korea
Ministry of Health and Welfare
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC00074C
Reference39 articles.
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