Hydroarylation of enamides enabled by HFIP <i>via</i> a hexafluoroisopropyl ether as iminium reservoir-Reference-Cited by-同舟云学术

Hydroarylation of enamides enabled by HFIP via a hexafluoroisopropyl ether as iminium reservoir

Published:2022 Issue:28 Volume:13 Page:8436-8443
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zeidan Nicolas¹,Bicic Sergiu¹,Mayer Robert J.¹^ORCID,Lebœuf David¹^ORCID,Moran Joseph¹^ORCID

Affiliation:

1. Institut de Science et d’Ingénierie Supramoléculaires (ISIS), CNRS UMR 7006, Université de Strasbourg, 8 allée Gaspard Monge, 67000 Strasbourg, France

Abstract

Hexafluoroisopropanol reversibly traps and releases iminium ions to greatly expand the scope of enamide hydroarylation, a mechanism that is likely common to other reactions featuring carbocations in that solvent.

Funder

Horizon 2020 Framework Programme

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC02012B

Reference62 articles.

1. S. A.Lawrence , Amines: Synthesis, Properties and Applications , Cambridge University Press , Cambridge , 2004

2. A.Ricci , Amino Group Chemistry: From Synthesis to the Life Science , Wiley-VCH , Weinheim , 2008