Affinity of fentanyl and its derivatives for the σ1-receptor-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Affinity of fentanyl and its derivatives for the σ1-receptor

Published:2019 Issue:7 Volume:10 Page:1187-1191
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Lipiński Piotr F. J.¹²³⁴⁵^ORCID,Szűcs Edina⁶⁷⁸⁹¹⁰,Jarończyk Małgorzata¹¹¹²⁵,Kosson Piotr¹³²³⁴⁵,Benyhe Sándor⁶⁷⁸⁹¹⁰,Misicka Aleksandra¹²³⁴⁵^ORCID,Dobrowolski Ján Cz.¹¹¹²⁵^ORCID,Sadlej Joanna¹⁴¹⁵¹⁶⁵

Affiliation:

1. Department of Neuropeptides

2. Mossakowski Medical Research Centre

3. Polish Academy of Sciences

4. 02-106 Warsaw

5. Poland

6. Institute of Biochemistry

7. Biological Research Centre

8. Hungarian Academy of Sciences

9. Szeged

10. Hungary

11. National Medicines Institute

12. 00-725 Warsaw

13. Toxicology Research Laboratory

14. Faculty of Mathematics and Natural Sciences

15. Cardinal Stefan Wyszyński University in Warsaw

16. 01-938 Warsaw

Abstract

Fentanyl has been found to only weakly bind the σ₁-receptor, and its close derivatives have submicromolar affinities.

Funder

Narodowe Centrum Nauki

Instytut Medycyny Doswiadczalnej i Klinicznej im. M. Mossakowskiego, Polskiej Akademii Nauk

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00222G

Reference27 articles.

1. Purification, molecular cloning, and expression of the mammalian sigma1-binding site.

2. Role of sigma-1 receptors in neurodegenerative diseases

3. The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

4. The pharmacology of sigma-1 receptors

5. Pharmacology and Therapeutic Potential of Sigma1 Receptor Ligands

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A Novel Bifunctional μOR Agonist and σ₁R Antagonist with Potent Analgesic Responses and Reduced Adverse Effects;Journal of Medicinal Chemistry;2023-11-28

2. IUPHAR Review - Bivalent and bifunctional opioid receptor ligands as novel analgesics;Pharmacological Research;2023-11

3. Evaluating the Pharmacokinetics of Fentanyl in the Brain Extracellular Fluid, Saliva, Urine, and Plasma of Newborns from Transplacental Exposure from Parturient Mothers Dosed with Epidural Fentanyl Utilizing PBPK Modeling;European Journal of Drug Metabolism and Pharmacokinetics;2023-08-10

4. Synthesis of Fentanyl Triazole Derivatives and their Affinity for Mu-Opioid and Sigma-1 Receptors;Journal of the Brazilian Chemical Society;2023

5. Benzylaminofentanyl derivates: Discovery of bifunctional μ opioid and σ1 receptor ligands as novel analgesics with reduced adverse effects;European Journal of Medicinal Chemistry;2022-11

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3