Decellularized scaffold-based poly(ethylene glycol) biomimetic vascular patches modified with polyelectrolyte multilayer of heparin and chitosan: preparation and vascular tissue engineering applications in a porcine model

Author:

Gao Huimin1,Hu Pengpeng1,Sun Gaoqi1,Wang Lei1,Tian Yu1,Mo Hong1ORCID,Liu Cheng2,Zhang Jun1,Shen Jian1

Affiliation:

1. Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, National and Local Joint Engineering Research Center of Biomedical Functional Materials, Jiangsu Engineering Research Center for Biomedical Function Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China

2. Medical School, Nanjing University, Nanjing 210093, P. R. China

Abstract

PEG/DCS surface was modified with heparin–chitosan PEM to construct a biomimetic vascular patch which could maintain long-term patency of the treated arteries in vivo.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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