Reversible, β-sheet-dependent self-assembly of the phosphoprotein phosvitin is controlled by the concentration and valency of cations-Reference-Cited by-同舟云学术

Reversible, β-sheet-dependent self-assembly of the phosphoprotein phosvitin is controlled by the concentration and valency of cations

Published:2022 Issue:19 Volume:24 Page:11791-11800
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Betschart Martin U.¹,Sarem Melika²³,Shastri V. Prasad²³,Lüdeke Steffen¹⁴^ORCID

Affiliation:

1. Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, 79104 Freiburg, Germany

2. Institute for Macromolecular Chemistry, Albert-Ludwigs-Universität Freiburg, Stefan-Meier-Str. 31, 79104 Freiburg, Germany

3. BIOSS – Centre for Biological Signalling Studies, Albert-Ludwigs-Universität Freiburg, 79104 Freiburg, Germany

4. Institut für Pharmazeutische und Biomedizinische Wissenschaften (IPBW), Johannes Gutenberg-Universität Mainz, Staudingerweg 5, 55128 Mainz, Germany

Abstract

At low pH, the hyperphosphorylated intrinsically disordered protein phosvitin undergoes a conformational transition to a β-sheet accompanied by slow protein–protein assembly. Different cations modulate this process in different ways.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CP/D1CP05493G

Reference63 articles.

1. Microfibrillar structure of type I collagen in situ

2. Pattern formation in centrosome assembly

3. The multifunctional nucleolus

4. Liquid-Liquid Phase Separation in Biology

5. Intrinsically disordered proteins in cellular signalling and regulation