Pipecolic esters as minimized templates for proteasome inhibition
Author:
Affiliation:
1. Department of Chemistry
2. Michigan State University
3. East Lansing
4. USA
5. Institute of Biotechnology
6. University of Texas Health Science Center at San Antonio
7. San Antonio
Abstract
Allosteric regulators of clinically important enzymes are gaining popularity as alternatives to competitive inhibitors.
Funder
William and Ella Owens Medical Research Foundation
San Antonio Area Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB00122K
Reference45 articles.
1. Proteasome Disassembly and Downregulation Is Correlated with Viability during Stationary Phase
2. Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway
3. The proteasome: a suitable antineoplastic target
4. Second Generation Proteasome Inhibitors: Carfilzomib and Immunoproteasome-Specific Inhibitors (IPSIs)
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