New cyclometalated Ru(<scp>ii</scp>) polypyridyl photosensitizers trigger oncosis in cancer cells by inducing damage to cellular membranes-Reference-Cited by-同舟云学术

New cyclometalated Ru(ii) polypyridyl photosensitizers trigger oncosis in cancer cells by inducing damage to cellular membranes

Published:2024 Issue:13 Volume:11 Page:3855-3876
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Cervinka Jakub¹²^ORCID,Hernández-García Alba³,Bautista Delia⁴,Markova Lenka²^ORCID,Kostrhunova Hana²^ORCID,Malina Jaroslav²^ORCID,Kasparkova Jana²⁵^ORCID,Santana M. Dolores³^ORCID,Brabec Viktor²⁵^ORCID,Ruiz José³^ORCID

Affiliation:

1. Faculty of Science, Department of Biochemistry, Masaryk University, CZ-62500 Brno, Czech Republic

2. Czech Academy of Sciences, Institute of Biophysics, CZ-61200 Brno, Czech Republic

3. Departamento de Química Inorgánica, Universidad de Murcia, and Murcia BioHealth Research Institute (IMIB-Arrixaca), E-30100 Murcia, Spain

4. ACTI, Universidad de Murcia, Murcia E-30100, Spain

5. Department of Biophysics, Faculty of Science, Palacky University, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic

Abstract

A new generation of benzimidazole-based cyclometalated ruthenium(ii) complexes with bpy or dpq as ancillary ligands are effective against hypoxic cancers via green light activation and can directly disrupt phospholipid membranes and trigger oncosis.

Funder

Akademie Věd České Republiky

Ministerio de Ciencia e Innovación

European Regional Development Fund

Fundación Séneca

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QI/D4QI00732H

Reference52 articles.

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4. Design of Near-Infrared-Triggered Metallo-Photosensitizers via a Self-Assembly-Induced Vibronic Decoupling Strategy

5. Clinical Development of Metal Complexes as Photosensitizers for Photodynamic Therapy of Cancer