Linear and branched polymer prodrugs of the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine as structural materials for long-acting implants-Reference-Cited by-同舟云学术

Linear and branched polymer prodrugs of the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine as structural materials for long-acting implants

Published:2022 Issue:23 Volume:10 Page:4395-4404
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Shakil Anika¹²³,Hern Faye Y.¹²³,Liu Chung¹²³,Temburnikar Kartik⁴,Chambon Pierre¹²³,Liptrott Neill³⁵^ORCID,McDonald Tom O.¹²³^ORCID,Neary Megan²³⁵,Owen Andrew²³⁵,Freel Meyers Caren⁴,Rannard Steve P.¹²³^ORCID

Affiliation:

1. Department of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD, UK

2. Materials Innovation Factory, University of Liverpool, Crown Street, L69 7ZD, UK

3. Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, L7 3NY, UK

4. Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe St., Baltimore, MD, 21205, USA

5. Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L7 3NY, UK

Abstract

Long acting release of the water soluble nucleoside reverse transcriptase inhibitor emtricitabine (FTC) has been demonstrated in vitro through polymer formation using FTC as a monomer, and forming implants made of the drug containing polymer.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D2TB00825D

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