Selective thiazoline peptide cyclisation compatible with mRNA display and efficient synthesis-Reference-Cited by-同舟云学术

Selective thiazoline peptide cyclisation compatible with mRNA display and efficient synthesis

Published:2023 Issue:38 Volume:14 Page:10561-10569
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liu Minglong¹²,Morewood Richard³,Yoshisada Ryoji¹²,Pascha Mirte N.⁴,Hopstaken Antonius J. P.¹²,Tarcoveanu Eliza³,Poole David A.¹²^ORCID,de Haan Cornelis A. M.⁴,Nitsche Christoph³^ORCID,Jongkees Seino A. K.¹²^ORCID

Affiliation:

1. Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

2. Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

3. Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia

4. Section Virology, Division Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands

Abstract

A new tool for peptide discovery. Pyridine-nitrile based macrocyclisation in mRNA display format, provides novel conformational constraints and allows construction of controlled bicyclic structures.

Funder

Australian Research Council

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC03117A

Reference42 articles.

1. Constrained peptides' time to shine?

2. Constrained Peptides in Drug Discovery and Development