Sennoside A is a novel inhibitor targeting caspase-1-Reference-Cited by-同舟云学术

Sennoside A is a novel inhibitor targeting caspase-1

Published:2022 Issue:19 Volume:13 Page:9782-9795
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Wu Jiasi¹²^ORCID,Lan Yuejia¹,Shi Xiaoke³,Huang Wenge¹,Li Sheng³,Zhang Jizhou²,Wang Huan¹,Wang Fei³,Meng Xianli¹

Affiliation:

1. State Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China

2. Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China

3. Key Laboratory of Natural Medicine and Clinical Translation, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China

Abstract

Sen A decreases caspase-1 activity and P2X7 function, which further leads to NLRP3 and AIM2 inflammasome disassembly and the reduced secretion of IL-1β and IL-18 via pyroptosis restraining and NF-κB-involved NLRP3 priming.

Funder

National Nature Science Foundation of China

National Key Research and Development Program of China

Chinese Academy of Sciences

Chengdu University of Traditional Chinese Medicine

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO01730J