Optimization of phthalazin-based aryl/heteroarylhydrazones to design new promising antileishmanicidal agents: synthesis and biological evaluation of 3-aryl-6-piperazin-1,2,4-triazolo[3,4-a]phthalazines-Reference-Cited by-同舟云学术

Optimization of phthalazin-based aryl/heteroarylhydrazones to design new promising antileishmanicidal agents: synthesis and biological evaluation of 3-aryl-6-piperazin-1,2,4-triazolo[3,4-a]phthalazines

Published:2020 Issue:32 Volume:44 Page:13807-13814
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Romero Angel H.¹²³⁴⁵^ORCID,Rodríguez Noris⁶⁷⁸³⁹,Ramírez Oscar G.¹²³⁴⁵

Affiliation:

1. Cátedra de Química General

2. Facultad de Farmacia

3. Universidad Central de Venezuela

4. Los Chaguaramos

5. Caracas 1041-A

6. Laboratorio de Ingeniería Genética

7. Instituto de Biomedicina

8. Facultad de Medicina

9. San Luis

Abstract

1-Monosubstituted and 1,4-substituted phthalazins based on aryl/heteroarylhydrazinyl have demonstrated attractive antileishmanial profiles against amastigote forms of the Leishmania braziliensis parasite.

Funder

Universidad Central de Venezuela

Consejo de Desarrollo Científico y Humanístico, Universidad Central de Venezuela

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NJ/D0NJ01206H

Reference67 articles.

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