Rhamnetin decelerates the elimination and enhances the antitumor effect of the molecular-targeting agent sorafenib in hepatocellular carcinoma cells via the miR-148a/PXR axis-Reference-Cited by-同舟云学术

Rhamnetin decelerates the elimination and enhances the antitumor effect of the molecular-targeting agent sorafenib in hepatocellular carcinoma cells via the miR-148a/PXR axis

Published:2021 Issue:6 Volume:12 Page:2404-2417
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Li Boan¹²³⁴⁵^ORCID,Feng Fan¹²³⁴⁵,Jia Hui⁶⁷⁸⁵⁹,Jiang Qiyu¹²³⁴⁵,Cao Shuang¹⁰¹¹¹²¹³¹⁴,Wei Ling¹⁵¹⁶¹⁷⁵,Zhang Yingshi⁶⁷⁸⁵,Lu Jincai⁶⁷⁸⁵⁹

Affiliation:

1. Center for Clinical Laboratory

2. The Fifth Medical Center

3. General Hospital of Chinese PLA

4. Beijing 100039

5. P.R. China

6. School of Traditional Chinese Materia

7. Shenyang Pharmaceutical University

8. Shenyang 110006

9. Liaoning Provincial Key Laboratory of TCM Resources Conservation and Development

10. Key Laboratory for Green Chemical Process of Ministry of Education

11. School of Chemical Engineering and Pharmacy

12. Wuhan Institute of Technology

13. Wuhan 430072

14. P. R. China

15. The Department of Quality Control

16. Beijing Centre for Physical and Chemical Analysis

17. Beijing 100089

Abstract

The pregnane X receptor (PXR) mediates the resistance of sorafenib in hepatocellular carcinoma (HCC) by promoting the clearance or elimination of sorafenib via the drug resistance-related downstream genes of the PXR. Rhamnetin drepresses the activation of PXR via miR-148a.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D0FO02270E

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