Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action-Reference-Cited by-同舟云学术

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Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

Published:2015 Issue:4 Volume:6 Page:2449-2456
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Babak Maria V.¹²³⁴⁵,Meier Samuel M.⁶⁷⁸⁹,Huber Kilian V. M.¹⁰⁸⁹,Reynisson Jóhannes¹²³⁴,Legin Anton A.⁵⁷⁸⁹,Jakupec Michael A.⁵⁷⁸⁹,Roller Alexander⁵⁷⁸⁹,Stukalov Alexey¹⁰⁸⁹,Gridling Manuela¹⁰⁸⁹,Bennett Keiryn L.¹⁰⁸⁹,Colinge Jacques¹⁰⁸⁹,Berger Walter¹¹¹²¹³⁸⁹,Dyson Paul J.¹⁴¹⁵¹⁶¹⁷,Superti-Furga Giulio¹⁰⁸⁹,Keppler Bernhard K.⁵⁷⁸⁹,Hartinger Christian G.¹²³⁴

Affiliation:

1. School of Chemical Sciences

2. University of Auckland

3. Auckland 1142

4. New Zealand

5. Institute of Inorganic Chemistry

6. Institute of Analytical Chemistry

7. University of Vienna

8. A-1090 Vienna

9. Austria

10. CeMM Research Center for Molecular Medicine

11. Department of Medicine I

12. Institute of Cancer Research

13. Medical University Vienna

14. Institut des Sciences et Ingénierie Chimiques

15. Ecole Polytechnique Fédérale de Lausanne (EPFL)

16. CH-1015 Lausanne

17. Switzerland

Abstract

The RAPTA pharmacophore was linked to beads to identify its biomolecular targets in cancer cells.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C4SC03905J

Reference47 articles.

1. Bioorganometallics: Future Trends in Drug Discovery, Analytical Chemistry, and Catalysis,

2. Organometallic Anticancer Compounds

3. Targeted therapy vs. DNA-adduct formation-guided design: thoughts about the future of metal-based anticancer drugs

4. Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

5. In Vitro and in Vivo Evaluation of Ruthenium(II)−Arene PTA Complexes

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