Palladium(ii) and platinum(ii) saccharinate complexes with bis(diphenylphosphino)methane/ethane: synthesis, S-phase arrest and ROS-mediated apoptosis in human colon cancer cells-Reference-Cited by-同舟云学术

Palladium(ii) and platinum(ii) saccharinate complexes with bis(diphenylphosphino)methane/ethane: synthesis, S-phase arrest and ROS-mediated apoptosis in human colon cancer cells

Published:2018 Issue:33 Volume:47 Page:11397-11410
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Icsel Ceyda¹²³⁴⁵,Yilmaz Veysel T.¹²³⁴⁵^ORCID,Aygun Muhittin⁶⁷⁸⁹⁵,Cevatemre Buse¹⁰²³⁴⁵,Alper Pinar¹¹¹²¹³¹⁴⁵,Ulukaya Engin¹¹¹²¹³¹⁴⁵

Affiliation:

1. Department of Chemistry

2. Faculty of Arts and Sciences

3. Uludag University

4. 16059 Bursa

5. Turkey

6. Department of Physics

7. Faculty of Sciences

8. Dokuz Eylul University

9. 35210 Izmir

10. Department of Biology

11. Department of Medical Biochemistry

12. Faculty of Medicine

13. University of Istinye

14. 34010 Istanbul

Abstract

Highly cytotoxic Pd(ii)/Pt(ii) complexes of saccharin with diphosphines cause cell arrest at the S phase and the production of excessive ROS, damaging mitochondria and DNA.

Funder

Türkiye Bilimsel ve Teknolojik Araştirma Kurumu

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/DT/C8DT02389A

Reference57 articles.

1. Metal complexes of saccharin

2. Synthesis and X-ray structure of the dinuclear platinum(II) complex with saccharin {K[Pt(sac)3(H2O)]·H2O}2: Studies on its antiproliferative activity in aqueous solution

3. Synthesis, characterization, structures and cytotoxic activity of palladium(II) and platinum(II) complexes containing bis(2-pyridylmethyl)amine and saccharinate