A novel catalytic heme cofactor in SfmD with a single thioether bond and a bis-His ligand set revealed by a de novo crystal structural and spectroscopic study-Reference-Cited by-同舟云学术

A novel catalytic heme cofactor in SfmD with a single thioether bond and a bis-His ligand set revealed by a de novo crystal structural and spectroscopic study

Published:2021 Issue:11 Volume:12 Page:3984-3998
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Shin Inchul¹²³^ORCID,Davis Ian¹²³^ORCID,Nieves-Merced Karinel¹²³⁴²,Wang Yifan¹²³^ORCID,McHardy Stanton¹²³⁴²^ORCID,Liu Aimin¹²³^ORCID

Affiliation:

1. Department of Chemistry

2. The University of Texas at San Antonio

3. USA

4. Center for Innovative Drug Discovery

Abstract

The de novo crystal structure of SfmD reveals a novel c-type heme cofactor for promoting a monooxygenation reaction in the biosynthetic pathway of saframycin A.

Funder

National Institute of General Medical Sciences

U.S. Department of Energy

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC06369J

Reference77 articles.

1. Characterization of the Saframycin A Gene Cluster from Streptomyces lavendulae NRRL 11002 Revealing a Nonribosomal Peptide Synthetase System for Assembling the Unusual Tetrapeptidyl Skeleton in an Iterative Manner