Role of the (pseudo)halido ligand in ruthenium(ii) p-cymene α-amino acid complexes in speciation, protein reactivity and cytotoxicity-Reference-Cited by-同舟云学术

Role of the (pseudo)halido ligand in ruthenium(ii) p-cymene α-amino acid complexes in speciation, protein reactivity and cytotoxicity

Published:2021 Issue:43 Volume:50 Page:15760-15777
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Biancalana Lorenzo¹^ORCID,Zanda Emanuele¹,Hadiji Mouna²,Zacchini Stefano³^ORCID,Pratesi Alessandro¹^ORCID,Pampaloni Guido¹^ORCID,Dyson Paul J.²^ORCID,Marchetti Fabio¹^ORCID

Affiliation:

1. University of Pisa, Dipartimento di Chimica e Chimica Industriale, Via G. Moruzzi 13, I-56124 Pisa, Italy

2. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland

3. University of Bologna, Dipartimento di Chimica Industriale “Toso Montanari”, Viale Risorgimento 4, I-40136 Bologna, Italy

Abstract

Replacement of the labile chlorido ligand with (pseudo)halides in Ru(ii) p-cymene α-amino acid complexes determines their speciation in water and in cell culture medium and reactivity with cytochrome c; yet does not confer cytotoxicity.

Funder

Università di Pisa

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/DT/D1DT03274G

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