Ultrasensitive small molecule fluorogenic probe for human heparanase-Reference-Cited by-同舟云学术

Ultrasensitive small molecule fluorogenic probe for human heparanase

Published:2021 Issue:1 Volume:12 Page:239-246
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liu Jun¹²³⁴⁵,Schleyer Kelton A.¹²³⁴⁵,Bryan Tyrel L.¹²³⁴,Xie Changjian¹²³⁴,Seabra Gustavo⁵⁶⁷⁸⁴,Xu Yongmei⁹¹⁰¹¹¹²⁴,Kafle Arjun¹²³⁴,Cui Chao¹²³⁴⁵,Wang Ying¹²³⁴,Yin Kunlun¹²³⁴,Fetrow Benjamin¹²³⁴,Henderson Paul K. P.¹²³⁴,Fatland Peter Z.¹²³⁴,Liu Jian⁹¹⁰¹¹¹²⁴,Li Chenglong⁵⁶⁷⁸⁴,Guo Hua¹²³⁴^ORCID,Cui Lina¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology

2. University of New Mexico

3. Albuquerque

4. USA

5. Department of Medicinal Chemistry

6. College of Pharmacy

7. University of Florida

8. Gainesville

9. Division of Chemical Biology and Medicinal Chemistry

10. Eshelman School of Pharmacy

11. University of North Carolina

12. Chapel Hill

Abstract

Heparanase, a critical enzyme involved in the remodeling of the extracellular matrix, activates a disaccharide probe HADP to give a strong fluorescence signal.

Funder

U.S. Department of Defense

National Institute of General Medical Sciences

National Institutes of Health

University of New Mexico

University of Florida

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC04872K