Arsenic(+3) and DNA methyltransferases, and arsenic speciation in tadpole and frog life stages of western clawed frogs (Silurana tropicalis) exposed to arsenate-Reference-Cited by-同舟云学术

Arsenic(+3) and DNA methyltransferases, and arsenic speciation in tadpole and frog life stages of western clawed frogs (Silurana tropicalis) exposed to arsenate

Published:2015 Issue:8 Volume:7 Page:1274-1284
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Koch Iris¹²³,Zhang Jing¹²³,Button Mark¹²³,Gibson Laura A.¹²³,Caumette Guilhem¹²³,Langlois Valerie S.¹²³,Reimer Kenneth J.¹²³,Cullen William R.⁴⁵³

Affiliation:

1. Department of Chemistry and Chemical Engineering

2. Royal Military College of Canada

3. Canada

4. Department of Chemistry

5. University of British Columbia

Abstract

Silurana tropicalistadpoles and frogs exposed to arsenate exhibit changes in levels of methylating enzymes DNMT1 and AS3MT, and methylate arsenic to trimethylarsine oxide and tetramethylarsonium.

Funder

Natural Sciences and Engineering Research Council of Canada

Canada Research Chairs

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MT/C5MT00078E

Reference59 articles.

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2. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells

3. Monomethylarsonous Acid (MMAIII) and Arsenite: LD50 in Hamsters and In Vitro Inhibition of Pyruvate Dehydrogenase

4. Comparative Toxicity of Arsenic Metabolites in Human Bladder Cancer EJ-1 Cells

5. In vitro toxicological characterization of two arsenosugars and their metabolites

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