Picoplatin binding to proteins: X-ray structures and mass spectrometry data on the adducts with lysozyme and ribonuclease A-Reference-Cited by-同舟云学术

Picoplatin binding to proteins: X-ray structures and mass spectrometry data on the adducts with lysozyme and ribonuclease A

Published:2024 Issue:20 Volume:53 Page:8535-8540
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Ferraro Giarita¹,Lyčková Tereza²,Massai Lara³,Štarha Pavel²^ORCID,Messori Luigi³^ORCID,Merlino Antonello¹^ORCID

Affiliation:

1. Department of Chemical Sciences, University of Naples Federico II, Complesso universitario di Monte Sant'Angelo, via Cinthia, 21, 80126, Naples, Italy

2. Department of Inorganic Chemistry, Faculty of Science, Palacký University Olomouc, 17. listopadu 12, 771 46 Olomouc, Czech Republic

3. Department of Chemistry “Ugo Schiff”, University of Florence, via della Lastruccia, 3-13, 50019, Sesto Fiorentino, Florence, Italy

Abstract

The reactivity of the anticancer drug picoplatin with the model proteins hen egg white lysozyme and bovine pancreatic ribonuclease was investigated by electrospray ionisation mass spectrometry and X-ray crystallography.

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D4DT00773E

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4. Preclinical and clinical overview of the novel platinum complex, ZD0473 (cis-amminedichloro[2-methylpyridine] platinum[II])