Expanding the scope of N → S acyl transfer in native peptide sequences-Reference-Cited by-同舟云学术

Expanding the scope of N → S acyl transfer in native peptide sequences

Published:2015 Issue:27 Volume:13 Page:7469-7476
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Cowper Ben¹²³⁴⁵,Shariff Leila¹²³⁴⁵,Chen Wenjie¹²³⁴⁵,Gibson Samantha M.¹²³⁴⁵,Di Wei-Li¹²³⁴⁵,Macmillan Derek¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. University College London

3. London

4. UK

5. Institute of Child Health

Abstract

A wider variety of Xaa-Cys motifs than originally envisaged were capable of undergoing efficient N → S acyl transfer to form thioesters and cyclic peptides, and our findings are applied to synthesis of wild-type Sunflower Trypsin Inhibitor-1 (SFTI-1).

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01029B

Reference63 articles.

1. Total chemical synthesis of proteins

2. Synthesis of Proteins by Native Chemical Ligation

3. Recent extensions to native chemical ligation for the chemical synthesis of peptides and proteins