Catalytic hydrogenation of N-4-nitrophenyl nicotinamide in a micro-packed bed reactor-Reference-Cited by-同舟云学术

Catalytic hydrogenation of N-4-nitrophenyl nicotinamide in a micro-packed bed reactor

Published:2018 Issue:4 Volume:20 Page:886-893
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Yang Cuixian¹²³⁴,Teixeira Andrew R.¹²³⁴^ORCID,Shi Yanxiang¹²³⁴,Born Stephen C.¹²³⁴,Lin Hongkun¹²³⁴^ORCID,Li Song Yunfei⁵⁶³⁷,Martin Benjamin⁸⁹¹⁰¹¹^ORCID,Schenkel Berthold⁸⁹¹⁰¹¹,Peer Lachegurabi Maryam¹²³⁴,Jensen Klavs F.¹²³⁴^ORCID

Affiliation:

1. Department of Chemical Engineering

2. Massachusetts Institute of Technology

3. Cambridge

4. USA

5. Department of Chemical Engineering and Biotechnology

6. University of Cambridge

7. UK

8. Novartis Pharma AG

9. Chemical and Analytical Development

10. Basel

11. Switzerland

Abstract

Recent advancements in micro-flow technologies and a drive toward more efficient, greener and safer processes have led to a renaissance in flow-chemistry for pharmaceutical production.

Funder

Novartis

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/GC/C7GC03469E

Reference36 articles.

1. Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions

2. Development of Pilot-Scale Continuous Production of an LY2886721 Starting Material by Packed-Bed Hydrogenolysis

3. End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation