HPLC-free in situ18F-fluoromethylation of bioactive molecules by azidation and MTBD scavenging-Reference-Cited by-同舟云学术

HPLC-free in situ18F-fluoromethylation of bioactive molecules by azidation and MTBD scavenging

Published:2019 Issue:78 Volume:55 Page:11798-11801
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Lu Yingqing¹²³⁴⁵,Choi Ji Young¹²³⁴⁵^ORCID,Kim Sang Eun¹²³⁴⁵,Lee Byung Chul¹²³⁴⁵^ORCID

Affiliation:

1. Department of Nuclear Medicine

2. Seoul National University College of Medicine

3. Seoul National University Bundang Hospital

4. Seongnam

5. Republic of Korea

Abstract

Sequential usage of azide and MTBD, which generates pure [¹⁸F]fluoromethyl tosylate and scavenges unreacted desmethyl precursors, provided an efficient HPLC-free strategy for the radio-synthesis of ¹⁸F-fluoromethylated compounds.

Funder

National Research Foundation of Korea

Ministry of Health and Welfare

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC04901K

Reference25 articles.

1. Positron Emission Tomography in oncology: Present and future of PET and PET/CT

2. Molecular imaging in drug development

3. Positron emission tomography molecular imaging for drug development

4. Fluorine in medicinal chemistry

5. 18F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography

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